Nebraska continued to rank among the nation's hot spots for COVID last week, with cases and hospitalizations both rising again.
Nebraska health care providers and educators on Tuesday launched a campaign to increase COVID-19 vaccination rates for children 5 and older with the goals of keeping kids healthy and in school.
More than 100 physicians and other health care providers from across the state so far have signed a statement of support for increasing vaccination among children and teens, said Chanda Chacón, president and CEO of Children’s Hospital & Medical Center.

Chacón
In addition, the hospital, in conjunction with the Nebraska Department of Education, launched the Max the Vax campaign, complete with a MaxthevaxNE.org website, to provide families with vaccination resources and information from trusted sources: Nebraska physicians and health care providers.
“We want parents to know they have a great resource in their family physicians and health care workers,” Chacón said. “They are here to support you.”
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Blomstedt
Matt Blomstedt, Nebraska’s education commissioner, said keeping kids healthy and in school is the most important thing parents and other adults can do, particularly in the face of all the disruptions the pandemic has wrought in people’s lives.
Studies indicate that missing even four days of school can have an impact on students, he said. Test scores of public school students released Monday also provide evidence that academic achievement took a hit from those disruptions.
Not only can vaccination protect kids and keep them in schools, he said, it also can prevent them from passing on the virus to vulnerable family members and others in their communities.
“This opportunity to max the vax really gives us the opportunity to unite in this,” Blomstedt said, noting that many schools already are hosting vaccination clinics with local health departments.

Stoolman
Dr. Sharon Stoolman, a pediatric hospital physician at Children’s, said Nebraska has room to increase vaccinations among its children, just as it does for adults.
According to the American Academy of Pediatrics, 4.3 million American children ages 5 to 11 had gotten at least one dose of COVID-19 vaccine as of Dec. 1. That represents 15% of that age group.
But vaccination rates vary greatly among states, ranging from 4% to 42%. In Nebraska, 17% of children ages 5 to 11 now have gotten at least one dose, according to federal Centers for Disease Control and Prevention data.
Nationally, 60% of 12- to 17-year-olds have gotten at least one dose, and 51% are fully vaccinated. In Nebraska, almost 54% of 12- to 17-year-olds have gotten at least one shot.
Many parents, the officials said, may be confused by myths and misinformation about getting their kids vaccinated.
Stoolman said the impact of the pandemic has been felt particularly in Black and brown, non-English-speaking and rural communities. That speaks to the urgency of making sure everyone has access not just to the vaccine but also to the information they need to make decisions about the shots.
With the delta variant still surging and omicron newly discovered in the state, Stoolman said, now is not the time to loosen protective measures.
While most children will have only mild illness when infected, she and her colleagues have cared for many kids who are very ill, both with COVID and with an inflammatory condition called Multisystem Inflammatory Syndrome in Children, or MIS-C. It can strike even children who have had mild COVID two to six weeks after the initial illness.

Sato
Dr. Alice Sato, hospital epidemiologist for Children’s, said the hospital has treated nearly 80 children with MIS-C since last May, many of whom have required intensive care and suffered effects on their hearts and other organs.
But many more children have been vaccinated. To her knowledge, she said, only one has been observed for potential heart impacts, which resolved quickly, with ibuprofen the only treatment.
Stoolman noted that some still question whether the vaccine is necessary for kids. “From my heart as a mom and my brain as a scientist and a pediatrician, I would say yes, the vaccine is necessary to keep kids out of the hospital and in the classroom.”
Stoolman said the vaccine for 5- to 11-year-olds went through additional testing for safety and proper dosing. Because of that, she feels even more secure that it wasn’t rushed.
“I know people may be sitting back and watching and waiting,” she said. “It’s critical now to make that appointment.”

Braun
Dr. Emily Braun, a pediatrician with OneWorld Community Health Centers, said she knows as a mom of four young children that new vaccines can cause anxiety. Health care providers are working to provide research and support and to make parents comfortable with the vaccines.
Braun also delivered her message in Spanish. The Max the Vax website currently is available in English, Spanish, Gujerati and Malay. Materials will be made available in many languages.
Stoolman said natural immunity from a previous infection with COVID-19 does offer some protection against the virus. But comparing the pandemic to a hurricane, she said a greater level of protection is needed — a poncho and raincoat and boots — than what’s required in a rainstorm. Natural immunity also may be less likely to hold up to new variants.
“It’s just to give you extra, to make sure you’re really prepared,” she said.
Sato said not everyone who gets infected gets a robust immune response. And researchers know that immunity wanes over time.
But people who have had COVID-19 and get vaccinated have a potent response, Sato said. Kids who have had COVID won’t have more side effects from the vaccine than those who haven’t been infected, Sato said.
How COVID-19 affects the brain
How COVID-19 affects the brain

A growing body of scientific evidence suggests some COVID-19 patients will experience neurological signs or symptoms of the infection. Genetic material from SARS-CoV-2, the virus that causes COVID-19, has been found in the cerebrospinal fluid of a person with COVID-19. And the virus has been found in the brain tissue of patients who died of COVID-19, which suggests it can affect the nervous system.
The frequency of symptoms appears to be associated with COVID-19 severity. In a study in China, patients with severe COVID-19 infection were more likely than those with nonsevere infection to have neurological symptoms of COVID-19, such as cerebrovascular disease, delirium, or musculoskeletal injury. Other neurological symptoms of COVID-19 include seizures and encephalitis.
The exact mechanisms by which SARS-CoV-2 affects the central and peripheral nervous systems is not clear. Neurological symptoms could be caused by the viral infection itself or be the result of other conditions such as sepsis, blood coagulation disorders, and vasculitis, which have all been reported in those with COVID-19. More research is needed, particularly as the number of people who have recovered from COVID-19 continues to grow.
Cognitive FX sought out information from scientific journals including The Lancet Psychiatry and the National Institutes of Health to put together a list of the six most common neurological symptoms associated with COVID-19 infection.
Cerebrovascular disorders

A 2020 study in The Lancet Psychiatry of almost 240,000 people with COVID-19 reported they had a little more than 2% rate of ischemic stroke. A subgroup of almost 9,000 people who were admitted to the intensive care unit had an almost 7% risk of ischemic stroke. In the same study, the rate of intracranial hemorrhage in those with COVID-19 was almost 1%, and the rate among those in the ICU was almost 3%. A small study in China reported that age, a history of diabetes or hypertension, severe COVID-19, and a significant inflammatory or coagulation response increased the risk of stroke in COVID-19 patients.
Anxiety disorder

A 2020 study that appeared in The Lancet Psychiatry reported that people diagnosed with COVID-19 had a more than 17% rate of anxiety disorder, and the rate among those admitted to the ICU with COVID-19 was greater than 19%. The researchers said the rate of psychiatric disorders such as mood and anxiety disorders was not as strongly associated with the severity of COVID-19 compared to the rate of neurological disorders, such as encephalopathy and stroke. This finding suggests anxiety disorder may reflect the psychological impact of a COVID-19 diagnosis, rather than being caused by the condition.
A review of 2020 research published in the international journal Acta Neurologica Belgica also found a relationship between COVID-19 and the onset of depressive conditions, especially in patients with severe cases of the virus.
Dementia

The findings of The Lancet Psychiatry study support previous evidence of an association between COVID-19 and dementia. The more recent study reported that almost 3% of those over 65 had a first diagnosis of dementia six months after their COVID-19 diagnosis. Almost 5% of those with encephalopathy had a first diagnosis of dementia six months after diagnosis.
Encephalopathy

People with a history of severe respiratory distress and hypertension have an increased risk of developing encephalopathy as the first symptom of COVID-19. The risk increases with the severity of the infection. COVID-19-associated encephalopathy may have multiple causes, including metabolic factors; medication; and hypoxia, or insufficient oxygen. The symptoms of encephalopathy are treated with anticonvulsant medication; antipyretic, or fever-reducing medication; and high-flow nasal cannula support for oxygen therapy.
Encephalitis

Encephalitis, or inflammation of the brain, is a type of encephalopathy that is caused by an infection, including a viral infection. Symptoms of encephalitis include fever, headache, and delirium. Patients with COVID-19 may also have seizures. Those with COVID-19 may present with encephalitis rather than respiratory symptoms, although it is rare. A July 2020 study published in the journal Brain, Behavior, and Immunity suggests a link between COVID-19 and encephalitis.
Myopathy and neuromuscular disorders

A study of patients with COVID-19 reported that 44% to 70% of those hospitalized had myalgia and fatigue. Unfortunately, the rapid spread of the novel coronavirus prevented a thorough workup of COVID-19 patients that may have helped doctors determine how the infection caused these symptoms. Myalgia correlates with increased creatinine kinase level and lymphocyte count, which suggests COVID-19 may cause muscle damage and could interfere with muscle energy production, according to a study published in March 2021 by the International Journal of Clinical Practice.
This story originally appeared on Cognitive FX and was produced and distributed in partnership with Stacker Studio.