Creighton surrendered a game-winning goal midway through the second half at DePaul Wednesday, falling to 0-3 in Big East play for the first time since joining the league.
The Jays were out-shot 8-1 in the second half. The Blue Demons (6-4, 2-1) came through with the decisive goal in the 63rd minute.
CU was coming off a week where it defeated UNO and Illinois-Chicago by a combined score of 5-0. But it couldn't carry the momentum back into conference play.
Creighton's Big East season started last month with a heartbreaking 2-1 defeat to Georgetown in the closing moments. The Jays (3-5-1, 0-3) lost 2-0 at St. John's one week later. They're tied for last place in the league standings after Wednesday's result.
Only once has CU finished with a losing record in Big East action since joining the league in 2013. It's never finished worse than fifth in the standings.
Creighton returns to action Saturday when it hosts Marquette.