Omaha scored four in the bottom of the first inning and maintained the lead the rest of Friday night in a 10-8 win over Columbus at Werner Park.
The Storm Chasers scored runs on Gabriel Cancel's single, a bases-loaded walk, a hit by pitch and a wild pitch.
Freddy Fermin's two-run double in the sixth inning made it 10-5 as Omaha held on from there.
Cancel had three hits for the Chasers while Vinnie Pasquantino scored three times.
The Chasers and Clippers play the fifth game of the six-game series at 6:35 p.m. Saturday.
Photos: Omaha Storm Chasers through the years